Work

Collaborative Power of Nrf2 and PPAR γ Activators against Metabolic and Drug‐Induced Oxidative Injury

Year: 2017

Type: review

Abstract: Mammalian cells have evolved a unique strategy to protect themselves against oxidative damage induced by reactive oxygen species (ROS). Especially, two transcription factors, nuclear factor erythroid 2p45‐related factor 2 (Nrf2) and peroxisome proliferator‐activated receptor γ (PPAR γ ), have been shown to play key roles in establishing this cellular antioxidative defense system. Recently, several researchers reported ameliorating effects of pharmacological activators for these Nrf2 and PPAR γ pathways on the progression of various metabolic disorders and drug‐induced organ injuries by oxidative stress. In this review, general features of Nrf2 and PPAR γ pathways in the context of oxidative protection will be summarized first. Then, a number of successful applications of natural and synthetic Nrf2 and PPAR γ activators to the alleviation of pathological and drug‐related oxidative damage will be discussed later.

Source: Oxidative Medicine and Cellular Longevity

DOI: 10.1155/2017/1378175

Author: Choongho Lee

Institution: Dongguk University

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680