Work

A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis

Year: 2017

Type: article

Abstract: A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. This hydrochlorination method could be conducted under open air.

Source: Organic Letters

DOI: 10.1021/acs.orglett.7b02101

Authors: Shengzong Liang, Rene Ebule, Gerald B. Hammond, Bo Xu

Institutions: University of Louisville, Donghua University

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Natural Science Foundation of China, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry