Work

Chemokines encoded by herpesviruses

Year: 2017

Type: article

Abstract: Viruses use diverse strategies to elude the immune system, including copying and repurposing host cytokine and cytokine receptor genes. For herpesviruses, the chemokine system of chemotactic cytokines and receptors is a common source of copied genes. Here, we review the current state of knowledge about herpesvirus-encoded chemokines and discuss their possible roles in viral pathogenesis, as well as their clinical potential as novel anti-inflammatory agents or targets for new antiviral strategies.

Source: Journal of Leukocyte Biology

DOI: 10.1189/jlb.4ru0417-145rr

Authors: Sergio M Pontejo, Philip M Murphy

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases