Work

Coordination of cardiac rhythmic output and circadian metabolic regulation in the heart

Year: 2017

Type: review

Abstract: Over the course of a 24-h day, demand on the heart rises and falls with the sleep/wake cycles of the organism. Cardiac metabolism oscillates appropriately, with the relative contributions of major energy sources changing in a circadian fashion. The cardiac peripheral clock is hypothesized to drive many of these changes, yet the precise mechanisms linking the cardiac clock to metabolism remain a source of intense investigation. Here we summarize the current understanding of circadian alterations in cardiac metabolism and physiology, with an emphasis on novel findings from unbiased transcriptomic studies. Additionally, we describe progress in elucidating the links between the cardiac peripheral clock outputs and cardiac metabolism, as well as their implications for cardiac physiology.

Source: Cellular and Molecular Life Sciences

DOI: 10.1007/s00018-017-2606-x

Authors: Paishiun Nelson Hsieh, Lilei Zhang, Mukesh Kumar Jain

Institutions: University Hospitals Cleveland Medical Center, Case Western Reserve University, Baylor College of Medicine

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,290