Work

Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma

Year: 2017

Type: review

Abstract: Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making.

Source: Blood

DOI: 10.1182/blood-2017-05-736975

Authors: Richard J. Lin, Madhusmita Behera, Catherine S. Diefenbach, Christopher R. Flowers

Institutions: Memorial Sloan Kettering Cancer Center, Emory University, Winship Cancer Institute, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute