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NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis

Year: 2017
Type: article
Abstract: emission in microcapillary tubes containing minute quantities of blood, to establish a novel method for minimally invasive pharmacokinetic monitoring. The in vivo circulatory half-life of the PEG-b-TCL-based micelles was found to be ∼19.6 h. Additionally, longitudinal in vivo imaging of orthotopically transplanted breast tumors enabled determination of micelle biodistribution that correlated to ex vivo imaging results, demonstrating accumulation predominantly within the tumors and livers of mice. The PEG-b-TCL-based micelles quickly extravasated within 4T1 orthotopic mammary carcinomas, exhibiting peak accumulation at ∼48 h following intravenous tail-vein injection. In summary, PEG-b-TCL-based micelles demonstrated favorable characteristics for further development as in vivo optical contrast agents for minimally invasive imaging of breast tumors.
Source: Nanoscale
DOI: 10.1039/c7nr02363d
Authors: Christina L. Hofmann, Melanie C. O'Sullivan, Alexandre Detappe, Yingjie Yu, Xi Yang, Wei Qi, Chelsea D. Landon, Michael J. Therien, Mark W. Dewhirst, P. Peter Ghoroghchian, Gregory M. Palmer
Institutions: Duke University, Harvard University, Dana-Farber Cancer Institute, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Duke Medical Center
Language: English
Open Access status: green
Awards: G2517684854, G422641088, Modulation of In Vivo Tumor Oxygenation via Polymersome-encapsulated Myoglobin, G8022602701, G8032995847, CIRCUMVENTING THERAPEUTIC RESISTANCE AND THE EMERGENCE OF DISSEMINATED BREAST CANCER CELLS THROUGH NONINVASIVE OPTICAL IMAGING
OpenAlex ID: W2750417882
FWCI: 1.166
Cites: 38
Cited by: 16
Related to: 10