A High Multivitamin Diet Fed To Wistar Rat Dams During Pregnancy Increases Later Life Maternal Weight Gain and Alters Homeostatic, Hedonic and Peripheral Regulatory Systems of Energy Balance.
Year: 2014
Type: dissertation
Abstract: High multivitamin (10-fold, HV) and high folic acid diets fed to pregnant Wistar rats increase obesity and components of the metabolic syndrome in the offspring, but the effects on the post-weaning maternal phenotype are unclear. The hypothesis that methyl group vitamins are determinants of the HV diet-induced phenotype in the mother when fed a high fat diet post-weaning through alterations in homeostatic, hedonic and peripheral regulatory systems was tested. Wistar rats were fed AIN-93G diets containing either 1) recommended multivitamins (RV, control), 2) HV 3) HV with recommended folic acid (HVRF; 1-fold folic acid), or 4) RV with high methyl group vitamins (HMethyl; 10-fold folic acid, vitamin B12 and B6) during pregnancy alone. All groups were fed a RV diet during lactation until weaning and a RV high fat (60% fat) diet for 16 weeks post-weaning. Dams fed the HV, HVRF and HMethyl diet gained more weight from 2 to 15 weeks post-weaning and their weight gain was dependent on post-weaning food intake. In contrast, only HV dams demonstrated hypo-functioning of mesolimbic reward pathway and higher expression of several genes in the hypothalamus and peripheral tissues involved in the regulation of energy balance. In conclusion, HV, HVRF and HMethyl diets fed during pregnancy predispose the mother to weight gain when exposed to a high fat diet post-weaning, however the diets were not consistent in their effects on central and peripheral regulatory systems leaving uncertain the primary mechanism(s) of action of vitamin-induced weight gain.
Source: TSpace (University of Toronto)
Author: Emanuela Pannia
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G7843668937
OpenAlex ID: W2750853734