Effects of Dietary Pulses on Lipids and Oxidative Stress as Risk Factors of Cardiovascular Disease
Year: 2013
Type: dissertation
Study designs: Systematic Review, Meta-Analysis
Abstract: The objective was to conduct a systematic review and meta-analysis of randomized feeding trials to assess the effect of dietary pulses (beans, chickpeas, lentils, peas) on established lipid targets of cardiovascular disease (CVD) and perform a secondary analysis of our randomized feeding trial to assess whether dietary pulses as a means of lowering the glycemic index offer further CVD protection by reducing oxidative stress. The meta-analysis of 26 trials (n=1013) found dietary pulse interventions significantly lowered LDL-C compared with isocaloric control interventions (mean difference=-0.17mmol/L [95% CI: -0.25, -0.09]; p<0.0001). No treatment effects were observed for Apo-B and non-HDL-C. Our feeding trial found no significant differences between the high-dietary pulse diet and high-fibre control diet on markers of oxidative stress, including thiobarbituric acid reactive substances (TBARS), conjugated dienes (CDs), and protein thiols. Overall, the results suggest dietary pulses reduce LDL-C but not oxidative stress as a means of reducing cardiovascular risk.
Source: TSpace (University of Toronto)
Author: Vanessa Ha
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: American Diabetes Association, U.S. Department of Agriculture, American Heart Association, Abbott Laboratories, World Health Organization, Kellogg's, California Strawberry Commission, Almond Board of California, Advanced Foods and Materials Network, Saskatchewan Pulse Growers, Canadian Cardiovascular Society, European Food Safety Authority, European Association for the Study of Diabetes, Alpro Foundation, Agriculture and Agri-Food Canada
OpenAlex ID: W2750908624