Cognition and Motor Function: A Novel Outcome Measure for Studies on Pre-Dementia Syndromes
Year: 2017
Type: article
Abstract: Advances in dementia research have shifted attention towards earlier stages in the natural history, such as Mild Cognitive Impairment. The current gold standard outcome measure, the Alzheimer’s Disease Assessment Scale-Cognitive Subscale, is not optimally responsive to changes in pre-dementia populations. Modifications to scoring methodology and content have improved the measurement performance of the ADAS-Cog. However, no published modifications have addressed a second key shift in the field towards understanding motor function as an important component of dementia and pre-dementia syndromes. This thesis used a Pooled Index approach to combine an ADAS-Cog-Proxy measure with assessments of gait velocity and dual-task cost. The responsiveness of the PI to baseline discrimination between older adults with normal cognition, Subjective Cognitive Impairment, and MCI was similar to the ADAS-Cog-Proxy. The PI demonstrated greater responsiveness than the ADAS-Cog-Proxy to change over 6mo. and 48mo., but not 36mo. of follow-up. Overall, motor function assessments improve ADAS-Cog responsiveness.
Author: Jacqueline K. Kueper
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1650819308, G2152643862, G2189010064, G2340207221, G2423387114, G2835601961, G29951154, G3131374986, G3216574877, G3553156159, G4119534169, G4475667458, G4800177743, G5207404921, G5324093878, G5654639750, G5850682332, G6210868510, G6371410416, G6792506723, G72415811, G764699806, G8228018387, G8895907669
OpenAlex ID: W2751123909