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The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

Year: 2017
Type: article
Abstract: transcription oscillates diurnally in intestinal epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells, STAT3 (signal transducer and activator of transcription 3), and the epithelial cell circadian clock. NFIL3 controls expression of a circadian lipid metabolic program and regulates lipid absorption and export in intestinal epithelial cells. These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism.
Source: Science
DOI: 10.1126/science.aan0677
Authors: Yuhao Wang, Zheng Kuang, Xiaofei Yu, Kelly A. Ruhn, Masato Kubo, Lora V. Hooper
Language: English
Open Access status: green
Funders: Howard Hughes Medical Institute, Burroughs Wellcome Fund, Welch Foundation, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1277860013, G1658098344, G3157716128, G4187857735, G4687809162, G5967554578, G8458773420, Integrative Immunology Training Grant, Microbial Regulation of Retinol Transport and its Role in Intestinal Immunity
OpenAlex ID: W2751705979
FWCI: 13.39
Cites: 37
Cited by: 453
Related to: 10