Nanoparticle Biokinetics in Mice and Nonhuman Primates
Year: 2017
Type: article
Abstract: Despite the preponderance of iron oxide nanoparticles (NPs) designed for theranostic applications, widespread clinical translation of these NPs lags behind. A better understanding of how NP pharmacokinetics vary between small and large animal models is needed to rapidly customize NPs for optimal performance in humans. Here we use noninvasive magnetic resonance imaging (MRI) to track iron oxide NPs through a large number of organ systems in vivo to investigate NP biokinetics in both mice and nonhuman primates. We demonstrate that pharmacokinetics are similar between mice and macaques in the blood, liver, spleen, and muscle, but differ in the kidneys, brain, and bone marrow. Our study also demonstrates that full-body MRI is practical, rapid, and cost-effective for tracking NPs noninvasively with high spatiotemporal resolution. Our techniques using a nonhuman primate model may provide a platform for testing a range of NP formulations.
Source: ACS Nano
Institutions: University of Washington, Fred Hutch Cancer Center
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: Targeted Modification of Host and Proviral DNA to Treat Latent HIV Infection, G1381271661, Multifunctional nanoparticles to improve treatment of human glioblastoma, Bruker Avance III 600 MHz (14T) Wide Bore Spectrometer, Evaluation of Pluripotent Stem Cell-Derived Blood Cells in Nonhuman Primate Model, Nanotechnology and Physical Science Training Program in Cancer Research
OpenAlex ID: W2751719831