Work

Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes

Year: 2017

Type: article

Abstract: We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au–Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air.

Source: ACS Catalysis

DOI: 10.1021/acscatal.7b02567

Authors: Rene Ebule, Shengzong Liang, Gerald B. Hammond, Bo Xu

Institutions: University of Louisville, Donghua University

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Natural Science Foundation of China, National Institute of General Medical Sciences