Genetics of intracranial aneurysms and related diseases
Year: 2017
Type: dissertation
Abstract: Intracranial aneurysms (IA) are dilatations of the vessel walls of cerebral arteries. Some can rupture and result in a subarachnoid hemorrhage (SAH), a severe subtype of stroke. This thesis is set out to elucidate the pathophysiology of IA from a genetic perspective. The main conclusions are: 1. Patients with IA at the middle cerebral artery have a higher burden of genetic risk factors than other IA patients; 2. No relevant RNA changes can be measured in blood of former SAH patients; 3. Low-frequent genetic variants in the FBLN2 gene are collectively associated with IA; 4. Intracranial, abdominal aortic (AAA) and thoracic aortic aneurysms (TAA) are both clinically and genetically different diseases, but they share some genetic risk variants; 5. Diseases which increase the risk on IA or AAA, also share part of their genetic backgrounds with IA or AAA.
Author: Femke N. G. van ’t Hof
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2752074286