Successful Treatment of Recurrent Li-Fraumeni Syndrome-related Choroid Plexus Carcinoma
Year: 2017
Type: article
Study design: Case Report
Abstract: The management of choroid plexus carcinoma (CPC) is challenging and multifaceted. Here, we discuss a 3-year-old girl with CPC and Li-Fraumeni syndrome who achieved full remission after surgery and chemotherapy, with radiation therapy spared. At recurrence, we used a novel, standard-dose cytotoxic chemotherapy regimen, focal proton radiation therapy, and targeted agents based on morphoproteomic analysis to achieve long-term survival. We highlight the rationale for our therapy at recurrence, as well as the risk-benefit analyses necessary in decision making for these patients. Our strategy may be effective in managing other patients with recurrent CPC and Li-Fraumeni syndrome.
Institutions: Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver, Children's Hospital Los Angeles, Dana-Farber Cancer Institute, Massachusetts General Hospital, University of Michigan, Michigan Medicine, The University of Texas Health Science Center at Houston, AbbVie (United States)
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G2233326982
OpenAlex ID: W2753029576