Year: 2017
Type: article
Study design: Observational Study
Abstract: The Mullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk. We investigated this association among women premenopausal at blood collection in a multicohort study including participants from eight studies located in the United States, Europe, and China. We identified 329 endometrial cancer cases and 339 matched controls. Anti-Mullerian hormone concentrations in blood were quantified using an enzyme-linked immunosorbent assay. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) across tertiles and for a doubling of AMH concentrations (OR log2 ). Subgroup analyses were performed by ages at blood donation and diagnosis, oral contraceptive use, and tumour characteristics. Anti-Mullerian hormone was not associated with the risk of endometrial cancer overall (OR log2 : 1.07 (0.99–1.17)), or with any of the examined subgroups. Although experimental models implicate AMH in endometrial cancer growth inhibition, our findings do not support a role for circulating AMH in the aetiology of endometrial cancer.
Source: British Journal of Cancer
DOI: 10.1038/bjc.2017.299
Authors: Renée T Fortner, Helena Schock, Seungyoun Jung, Naomi E Allen, Alan A Arslan, Louise A Brinton, Brian L Egleston, Roni T Falk, Marc J Gunter, Kathy J Helzlsouer, Annika Idahl, Theron S Johnson, Rudolf Kaaks, Vittorio Krogh, Eva Lundin, Melissa A Merritt, Carmen Navarro, N Charlotte Onland-Moret, Domenico Palli, Xiao-Ou Shu, Patrick M Sluss, Paul N Staats, Antonia Trichopoulou, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Wei Zheng, Joanne F Dorgan
Institutions: German Cancer Research Center, University of Maryland, Baltimore, University of Oxford, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University, Division of Cancer Epidemiology and Genetics, Fox Chase Cancer Center, Centre international de recherche sur le cancer, National Cancer Institute, Umeå University, Fondazione IRCCS Istituto Nazionale dei Tumori, Imperial College London, Instituto Murciano de Investigación Biosanitaria, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad de Murcia, University Medical Center Utrecht, Istituto per lo Studio e la Prevenzione Oncologica, Vanderbilt University, Harvard University, National and Kapodistrian University of Athens, Hellenic Health Foundation, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Funders: World Health Organization, New York City Department of Health and Mental Hygiene, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Vetenskapsrådet, NordForsk, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Hellenic Health Foundation, National Institutes of Health, Centers for Disease Control and Prevention, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, National Cancer Institute, National Institute of Environmental Health Sciences
Awards: G1032970344, G1055973116, G1075502044, G1090603134, G1192877484, G1208621354, G1241080153, G1274701479, G1318397260, G1478484880, G1559294051, G156276794, G172151099, G1734361364, G1767199718, G1788645866, G1907752718, G1952936224, G1993546569, G2027148636, G2072618322, G2099427675, G2131326840, G2149779140, G2235605558, G2336049343, G2409987178, G2539064604, G2561548287, G2572521044, G2611591051, G2709920838, G273148272, G2742323354, G2788466971, G2802736426, G2841678936, G2871896171, G29072894, G2933204024, G2999139090, G3010599472, G3049845011, G3077395769, G3084320185, G3149246560, G3170664214, G3189789075, G3216658785, G331404038, G3461390129, G3544161537, G3747421453, G375319704, G3816092139, G382879149, The NYU Women's Health Study, G3980646122, G4012977212, G4015156572, G4041385912, G4081633361, G4089957676, G4095281385, Vitamin D, Related Genes and Breast Cancer Risk, G4187108342, G4213141252, G423622538, G4303038735, G43956866, The RANK-Axis in Breast Cancer: A comprehensive prospective evaluation of promising novel biomarkers, G4473162978, Health of vegetarians, G459595259, G4752739612, G4811780622, G4879533352, G4884057766, G4913827001, G5004963360, G5047213743, G5119219000, G5375816427, G5406065712, G5456958854, G5578953934, G558017500, G5651954792, G569447510, G569908600, G5706284561, G5750710683, G5897142711, G5932924763, G5990830295, G6085534252, NIHR Senior Investigator Award, G6212483348, G6238616637, G6264211199, Prospective Study of Serum MIS and Gynecologic Cancer Risk, G6305665937, G6320156643, G640002926, G6442500046, G657255654, G6594529311, G6820515600, G6960682749, G7022277044, G7426181285, G7447125227, G7597388277, G7600088736, G7646326732, G7853538257, G7993655663, G8012318887, G8050896463, G817390530, G8279237360, G8331243404, G8374761964, G8477022045, G848473175, G8500560359, G8508326818, G8525262851, G8716998914, G876765158, G8867963557, G8959392569, G8978728421, G9000000197, G9000041999, G9000056458, G9000059258, G9000086364, G9000102578, G9000139424, G9000184592, G9000332718
OpenAlex ID: W2753465402