High Dietary Fiber is Associated with Reduced Prevalence of Gut Colonization by Multi-Drug-resistant Organisms
Year: 2017
Type: conference-abstract
Abstract: Prevention of multidrug-resistant organism (MDRO) infections, such as those caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and fluoroquinolone-resistant Gram-negative bacteria (FQRGNB), is crucial. Dietary fiber increases gut microbial diversity, which may help prevent colonization and subsequent infection by MDROs. The purpose of this study was to examine the association between dietary fiber consumption and gut colonization by MDROs. Data were analyzed on the first 225 adult participants of the 2016 wave of the Survey of the Health of Wisconsin (SHOW), and its ancillary microbiome study, the Winning the War on Antibiotic Resistance in Wisconsin (WARRIOR) project. SHOW is a population-based health survey collecting data on a wide range of health determinants and outcomes, as well as objective body measurements and biological specimens. In addition, WARRIOR added the following components: screening for MDRO risk factors, extensive diet questionnaires, and collection of biological specimens for microbial analysis. Logistic regression was used to evaluate the association between quartiles of fiber consumption and dichotomous MDRO colonization of stool samples, adjusted for age and sex. The study population was 92% White (Non-Hispanic), 55% female, and 48% age 50–69 years old, with 71% having attended at least some college. Median daily total fiber intake was 17.6g, with 6.6g and 10.1g median soluble and insoluble fiber, respectively. Vegetables were the largest contributor to dietary fiber with 1.5 median servings per day. The most frequent risk factor for MDRO colonization was antibiotic use in the past year (38%). Prevalence of positive stool samples was 0.5% for MRSA, 4% for VRE, and 11% for FQRGNB. Relative to the first quartile of fiber consumption, individuals in the third (OR 0.59, 95% CI 0.20–1.78) and fourth (OR 0.58, 95% CI 0.19-1.82) quartiles had lower odds of MDRO colonization after adjusting for age and sex. These results suggest a possible beneficial relationship between dietary fiber intake and MDRO gut colonization. Larger studies adjusting for multiple confounders and analysis of the role of different types of fiber are needed. All authors: No reported disclosures.
Source: Open Forum Infectious Diseases
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W2753617872