Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Year: 2017
Type: article
Abstract: Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood to optimize pharmacotherapy. It considers the interindividual variability of pharmacokinetics and thus enables personalized pharmacotherapy. In psychiatry and neurology, patient populations that may particularly benefit from TDM are children and adolescents, pregnant women, elderly patients, individuals with intellectual disabilities, patients with substance abuse disorders, forensic psychiatric patients or patients with known or suspected pharmacokinetic abnormalities. Non-response at therapeutic doses, uncertain drug adherence, suboptimal tolerability, or pharmacokinetic drug-drug interactions are typical indications for TDM. However, the potential benefits of TDM to optimize pharmacotherapy can only be obtained if the method is adequately integrated in the clinical treatment process. To supply treating physicians and laboratories with valid information on TDM, the TDM task force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) issued their first guidelines for TDM in psychiatry in 2004. After an update in 2011, it was time for the next update. Following the new guidelines holds the potential to improve neuropsychopharmacotherapy, accelerate the recovery of many patients, and reduce health care costs.
Source: Pharmacopsychiatry
Authors: C. Hiemke, N. Bergemann, H. Clement, A. Conca, J. Deckert, K. Domschke, G. Eckermann, K. Egberts, M. Gerlach, C. Greiner, G. Gründer, E. Haen, U. Havemann-Reinecke, G. Hefner, R. Helmer, G. Janssen, E. Jaquenoud, G. Laux, T. Messer, R. Mössner, M. Müller, M. Paulzen, B. Pfuhlmann, P. Riederer, A. Saria, B. Schoppek, G. Schoretsanitis, M. Schwarz, M. Gracia, B. Stegmann, W. Steimer, J. Stingl, M. Uhr, S. Ulrich, S. Unterecker, R. Waschgler, G. Zernig, G. Zurek, P. Baumann
Institutions: University Medical Center of the Johannes Gutenberg University Mainz, University of Freiburg, Universitätsklinikum Würzburg, University Medical Center Freiburg, Federal Institute for Drugs and Medical Devices, RWTH Aachen University, University of Regensburg, University of Göttingen, Vitos, Kanton Aargau, University of Tübingen, Innsbruck Medical University, Universität Innsbruck, Isar-Amper-Klinikum München-Ost, University of Bern, Ludwig-Maximilians-Universität München, Technical University of Munich, Max Planck Institute of Psychiatry, Landeskrankenhaus Feldkirch, University of Lausanne
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2753966476