Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects
Year: 2017
Type: article
Abstract: mice was associated with excess FA accumulation in the skeletal muscle. Treatment of these mice with an FABP4 inhibitor abrogated these metabolic phenotypes. These findings provide mechanistic insights that could greatly expand the therapeutic repertoire for type 2 diabetes and related metabolic disorders.
Source: Science Translational Medicine
Authors: Cheol Hwangbo, Jingxia Wu, Irinna Papangeli, Takaomi Adachi, Bikram Sharma, Saejeong Park, Lina Zhao, Hyekyung Ju, Gwang-woong Go, Guoliang Cui, Mohammed Inayathullah, Judith K. Job, Jayakumar Rajadas, Stephanie L. Kwei, Ming O. Li, Alan R. Morrison, Thomas Quertermous, Arya Mani, Kristy Red-Horse, Hyung J. Chun
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Howard Hughes Medical Institute, American Diabetes Association, U.S. Department of Veterans Affairs, American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, Actelion Pharmaceuticals
Awards: G119895177, CardioPulmonary Vascular Biology COBRE, G2739435298, Genetic and physiological causes of inherited Vascular and Metabolic Diseases, G2766351402, G2777112485, G2940777275, Vanderbilt Mouse Metabolic Phenotyping Center, Role of MicroRNAs 424 and 503 in Pulmonary Arterial Hypertension, Yale Cardiovascular Center faculty recruitment, Vanderbilt Mouse Metabolic Phenotyping Center, The Identification and characterization of genetic variants underlying cardiovascular diseases, Nutrient Sensing and mTORC1 Signaling in the Control of Regulatory T Cell Generation and Function, G479617472, G5822850130, G6191685371, G6495404200, G6731345426, G6991607900, Mechanotransduction and transcriptional regulation during artery development, Role of Apelin in the Systemic and Pulmonary Vasculature, G7882011945, G792016239, G8413681444, Cancer Center Support Grant, Yale Clinical and Translational Science Award
OpenAlex ID: W2754411658