A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging
Year: 2017
Type: conference-paper
Abstract: Both optical coherence tomography (OCT) and selective plane illumination microscopy (SPIM) are frequently used in mouse embryonic research for high-resolution three-dimensional imaging. Each of these imaging methods provide a unique and independent advantage: SPIM provides morpho-functional information through immunofluorescence and OCT provides a method for whole-embryo 3D imaging. In this study, we have combined rotational imaging OCT and SPIM into a single, dual-modality device to image E9.5 mouse embryos. The results demonstrate that the dual-modality setup is able to provide both anatomical and functional information simultaneously for more comprehensive tissue characterization.
Authors: Chen Wu, Shihao Ran, Henry Le, Manmohan Singh, Irina V. Larina, David Mayerich, Mary E. Dickinson, Kirill V. Larin
Institutions: University of Houston, Baylor College of Medicine
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2754512133