Work

The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design

Year: 2017

Type: review

Abstract: The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of T. gondii CDPK1.

Source: Parasitology

DOI: 10.1017/s0031182017001901

Authors: EMILY M. CARDEW, CHRISTOPHE L. M. J. VERLINDE, EHMKE POHL

Institutions: Durham University, University of Washington

Language: English

Topic: Toxoplasma gondii Research Studies

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550