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Synthesis and Antibacterial Activity of Aromatic Homopropargyl Alcohols

Year: 2017

Type: article

Abstract: Several aromatic homopropargyl alcohols, and derivatives were prepared by one-pot reaction of 1,3-dilithiopropyne (or its equivalent) with aldehydes and ketones. The antibacterial activity, of alcohols thus prepared, against Gram (+) and Gram (-) bacteria was tested. This activity varies depending upon substitution on the homopropargyl alcohol unit. Apparently, the benzene ring and the free hydroxyl group (or its alcoxide) are needed, in the homopropargyl alcohol unit, to be biologically active.

Source: International Journal of Organic Chemistry

DOI: 10.4236/ijoc.2017.73023

Authors: Christian A. Umaña, María L. Arias, Jorge A. Cabezas

Institution: Universidad de Costa Rica

Language: English

Topic: Coordination Chemistry and Organometallics

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Universidad de Costa Rica

OpenAlex ID: W2755780884