Work

Statins and Cognition in Parkinson’s Disease

Year: 2017

Type: article

Abstract: BACKGROUND: The relationship between statins and cognition in Parkinson's disease (PD) is poorly understood. OBJECTIVES: Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD. METHODS: Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally. RESULTS: At baseline, statin users (SU; N = 129) were older, more likely male, and had shorter PD duration than non-statin users (NSU; N = 184). In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long-term global cognitive (Dementia Rating Scale-2 and MoCA) decline was significantly less in SU.

Source: Journal of Parkinson s Disease

DOI: 10.3233/jpd-171113