Year: 2017
Type: article
Study design: Observational Study
Abstract: Animal and experimental data suggest that anti‐Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case‐control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme‐linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable‐adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable‐adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59–1.67) (Ptrend: 0.91). The association did not differ by age at blood draw or oral contraceptive use (all Pheterogeneity: ≥0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all Pheterogeneity: ≥0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer.
Source: International Journal of Cancer
DOI: 10.1002/ijc.31058
Authors: Seungyoun Jung, Naomi Allen, Alan A. Arslan, Laura Baglietto, Aurelio Barricarte, Louise A. Brinton, Brian L. Egleston, Roni T. Falk, Renée T. Fortner, Kathy J. Helzlsouer, Yutang Gao, Annika Idahl, Rudolph Kaaks, Vittorio Krogh, Melissa A. Merritt, Eva Lundin, N. Charlotte Onland‐Moret, Sabina Rinaldi, Helena Schock, Xiao‐Ou Shu, Patrick M. Sluss, Paul N. Staats, Carlotta Sacerdote, Ruth C. Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley S. Tworoger, Kala Visvanathan, Elisabete Weiderpass, Anne Zeleniuch‐Jacquotte, Joanne F. Dorgan
Institutions: University of Maryland, Baltimore, University of Oxford, NYU Langone Health, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University, The University of Melbourne, Cancer Council Victoria, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Fox Chase Cancer Center, German Cancer Research Center, Johns Hopkins University, Shanghai Cancer Institute, Umeå University, Fondazione IRCCS Istituto Nazionale dei Tumori, Imperial College London, University Medical Center Utrecht, Centre international de recherche sur le cancer, Vanderbilt University, Harvard University, Piedmont Reference Center for Epidemiology and Cancer Prevention, University of Turin, Danish Cancer Society, National and Kapodistrian University of Athens, Hellenic Health Foundation, Brigham and Women's Hospital, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, New York City Department of Health and Mental Hygiene, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Vetenskapsrådet, NordForsk, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Hellenic Health Foundation, National Institutes of Health, Centers for Disease Control and Prevention, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, National Cancer Institute, National Institute of Environmental Health Sciences
Awards: G1032970344, G1055973116, G1075502044, G1090603134, G1192877484, G1208621354, G1241080153, G1274701479, G1318397260, G1559294051, Biochemical Markers in the nurses' Health Study Cohort, G1718233269, G172151099, G1767199718, G1788645866, G1837345911, G1889983372, G1892934672, G1907752718, G1952936224, G1993546569, G2072618322, G2131326840, G2149779140, G2235605558, G2336049343, G2409987178, G2430964124, G2539064604, G2561548287, G2572521044, G2611591051, G2709920838, G2723675273, G273148272, G2742323354, G2791473063, G2841678936, G2871896171, Cancer Risk Reduction and Diet: A Cohort Study of Women, G29072894, G3010599472, G3049845011, G3050894790, G3063207948, G3077395769, G308111892, G3084320185, G3149246560, G3160575273, G3170664214, G3189789075, G3216658785, G331404038, G3461390129, G3496671490, G3544161537, G3576958170, G3668259588, G3747421453, G375319704, G3816092139, G382879149, The NYU Women's Health Study, G3964026636, Dietary and Hormonal Determinants of Cancer in Women, G3980646122, G4012977212, G4015156572, G4041385912, G4081633361, G4089957676, G4155712275, G4213141252, G423622538, G4303038735, G43956866, G4473162978, Health of vegetarians, G459566519, G459595259, G4735631659, G4752739612, G4773629080, G4811780622, G4879533352, G4884057766, G4913827001, G4964662507, G5004963360, G5047213743, G5058997197, G5069802979, G5119219000, G5294110089, G5375816427, G5406065712, G5456958854, G547275475, Research in Environmental Health Sciences, G5578953934, G558017500, G5651954792, G569447510, G569908600, G5706284561, G5750710683, G5768527752, G5897142711, G5932924763, G5990830295, G6025337639, G6085534252, Biomarkers and Breast Cancer Risk Prediction in Younger Women, NIHR Senior Investigator Award, G6212483348, G6238616637, G6264211199, Prospective Study of Serum MIS and Gynecologic Cancer Risk, G6305665937, G6320156643, G640002926, G640459779, G6442500046, G6473583094, G657255654, G6594529311, G6719391877, G6723261869, G6727411954, G6780254327, G6820515600, G6960682749, G7022277044, G707346186, G7426181285, G7447125227, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, G7600088736, G7646326732, G7853538257, G7993655663, G8012318887, G8050896463, G817390530, G8279237360, G8331243404, G8374761964, Shanghai Womens Health Study, G8461568454, G848473175, G8500560359, G8508326818, G8525262851, G8716998914, G876765158, G88130622, G8867963557, G8959392569, G8978728421, G9000019617, G9000059258, G9000152200, G9000184592, G9000190097, G9000288726, Cancer Center Support Grant
OpenAlex ID: W2755966584