Work

Genetic and epigenetic studies of adiposity and cardiometabolic disease

Year: 2017

Type: article

Abstract: Over 300 million adults are obese, but little is known about the impact of obesity on cardiovascular health. We discuss recent genetic and epigenetic studies of adiposity that indicate a causal role for general and central adiposity in cardiometabolic disease, and highlight potential mechanisms including insulin resistance and gene expression.

Source: Genome Medicine

DOI: 10.1186/s13073-017-0474-5

Authors: Michael V. Holmes, Sara L. Pulit, Cecilia M. Lindgren

Institutions: National Institute for Health and Care Research, University of Bristol, University of Oxford, MRC Population Health Research Unit, MRC Integrative Epidemiology Unit, Broad Institute, University Medical Center Utrecht, Centre for Human Genetics, NIHR Oxford Biomedical Research Centre

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,290

Funders: Li Ka Shing Foundation, National Institute for Health and Care Research, National Institutes of Health, Medical Research Council, NIHR Oxford Biomedical Research Centre, National Center for Research Resources

Awards: G3750575142, General Clinical Research Center, G9000156922

OpenAlex ID: W2756209642

FWCI: 2.125

Cites: 12

Cited by: 19

Related to: 10