Work

5-HTTLPR × stress hypothesis: is the debate over?

Year: 2017

Type: letter

Abstract: We read with great interest the impressive meta-analysis by Culverhouse et al. , 1 the largest and most comprehensive study to investigate whether 5-HTTLPR genotype modifies the association between stress and depression. Their findings based on 31 studies totaling 38 802 individuals of European ancestry do not support the interaction hypothesis between 5-HTTLPR genotype and stress (childhood maltreatment and broad life stress) on depression (lifetime or current). The authors also examined the possible effects of sex and age (as both a covariate and investigating specifically the 21–30 years age group), as well as genetic models (dominant, recessive), but again failed to find strong evidence of an interaction. The findings of this meta-analysis contrast with the original report that S allele carriers of 5-HTTLPR compared with LL had an increased risk of depression following a stressful event. 2

Source: Molecular Psychiatry

DOI: 10.1038/mp.2017.195

Authors: M-L Ancelin, J Ryan

Institutions: Inserm, Université de Montpellier, Neuropsychiatrie : Recherche Epidemiologique et Clinique, Monash University

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,804