Work

Promises and pitfalls of immune-based strategies for Huntington's disease

Year: 2017

Type: review

Abstract: Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD.

Source: Neural Regeneration Research

DOI: 10.4103/1673-5374.215245

Authors: AntonioLucio Teixeira, GabrielaDelevati Colpo, ErinFurr Stimming, NataliaPessoa Rocha

Institution: The University of Texas Health Science Center at Houston

Language: English

Topic: Genetic Neurodegenerative Diseases

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500