Work

The effect of mitochondrial dysfunction on astrocytes and radial glia like stem cells in the adult hippocampus

Year: 2013

Type: dissertation

Abstract: Cognitive decline is frequently observed in our ageing population, while the underlying cellular and molecular mechanisms are not fully understood. Age related neurodegeneration and loss of neuronal function can be correlated with impaired mitochondrial integrity and reduced oxidative phosphorylation. Astrocytes, required for an intact brain physiology, outnumber neurons by many times. This mouse study examines the consequences of mitochondrial dysfunction in astrocytes in particular on adult neurogenesis.

Source: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Author: Birgit Ebert

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2757419977

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