Work

Human evolution: the non-coding revolution

Year: 2017

Type: review

Abstract: What made us human? Gene expression changes clearly played a significant part in human evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics enabled the identification of human accelerated regions (HARs) and other human-specific genome sequences. The major challenge in the past decade has been to link diverged sequences to uniquely human biology. This review discusses approaches to this problem, progress made at the molecular level, and prospects for moving towards genetic causes for uniquely human biology.

Source: BMC Biology

DOI: 10.1186/s12915-017-0428-9

Authors: Lucía F. Franchini, Katherine S. Pollard

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Gladstone Institutes, University of California, San Francisco

Language: English

Topic: Chromosomal and Genetic Variations

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,690

Funder: Gladstone Institutes