Year: 2017
Type: review
Abstract: Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can leave a long-lasting imprint on the immune system in general and affect responses toward other pathogens and vaccines. This review aims to provide an overview of NK cell biology and development, the manipulation of NK cells by CMVs and the potential impact of these evasion strategies on responses to vaccination.
Source: European Journal of Immunology
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funders: European Commission, Department for International Development, European Union Agency for Network and Information Security, Hrvatska Zaklada za Znanost, Innovative Medicines Initiative, Medical Research Council, Biotechnology and Biological Sciences Research Council, H2020 European Research Council, FP7 Ideas: European Research Council
Awards: G1537430864, Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector, Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance, G434337789, G5374262212, Development of a Prophylactic Ebola Vaccine Using an Heterologous Prime-Boost Regimen: Phase II - Sofia ref.: 115861, G7066232665, Host responses underlying immunity, G7820508045, G8582019789
OpenAlex ID: W2758191434