Work

Pancreatic islet dysfunction is partially attenuated by replacement of dietary saturated fatty acids with monounsaturated fatty acids

Year: 2017

Type: article

Abstract: Previous work has established that different dietary fats can have varying impacts on metabolism and insulin sensitivity Specifically, saturated fatty acids (SFA) drive insulin resistance and inflammation, while dietary monounsaturated fatty acids (MUFA) do not disrupt metabolism to the same extent Moreover, feeding a high-fat diet (HFD) enriched with MUFA, rather than SFA-HFD, causes less IL-1 mediated inflammation, insulin resistance and hyperinsulinemia Our aim was to establish whether switching to a MUFA-based diet after previously feeding a SFA-based diet could ameliorate hyperinsulinemia, inflammatory markers and pancreatic islet function.

Source: Proceedings of The Nutrition Society

DOI: 10.1017/s0029665117001288