Work

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Year: 2016

Type: article

Source: Leukemia

DOI: 10.1038/leu.2016.131

Authors: B M Richine, E L Virts, J D Bowling, B Ramdas, R Mali, R Naoye, Z Liu, Z-Y Zhang, H S Boswell, R Kapur, R J Chan

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Indiana University, Purdue University West Lafayette

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Center for Advancing Translational Sciences

Awards: Novel Mechanisms of C-Kit Regulation in Mast Cells, The Role of Shp2 Phosphatase Activity in FLT3-ITD+ Acute Myeloid Leukemia, Indiana Clinical and Translational Sciences Institute, Role of Vav and Rac in KIT oncogenesis, Role of Shp2 in FLT3-ITD induced leukemogenesis, Indiana Clinical and Translational Science Institute (UL1), Role of p21 activated kinase in Leukemogenesis, Structure/Function of Protein Tyrosine Phosphatases, Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant

OpenAlex ID: W2417529916

FWCI: 1.566

Cites: 12

Cited by: 26

Related to: 10