Work

Sestrin1, a tumor suppressor that can be rescued

Year: 2017

Type: article

Abstract: SESTRIN1 is a tumor suppressor in follicular lymphoma that controls mTORC1 activity and it is inactivated by chromosomal deletions or epigenetically silenced by mutant EZH2Y641X. Pharmacological inhibition of EZH2 promotes SESTRIN1 re-expression and it restores its tumor suppressive activity, suggesting the possibility to epigenetically control mTORC1 activity.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2017.1365107

Authors: Maria C. Donaldson, Natalya Katanayeva, Elisa Oricchio

Institution: École Polytechnique Fédérale de Lausanne

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590