Starvation Diabetes, The Reason for the Use of Glucose in the Treatment of Diabetic Acidosis.
Year: 1945
Type: article
Abstract: In 1874 Lehmann50 noticed that injection of sugar into the mesenteric veins produced greater glycosuria in fasted than in fed dogs. In 1890 Hofmeister40 found that the administration of starch-gruel to previously fasted dogs often provoked glycosuria. Since then the phenomenon of starvation diabetes has been repeatedly reported in one connection or another; but its implications have not been fully recognized in the interpretation of physiological experiments and haave received scant attention in the clinic. Its significance in connection with the treatment of diabetic acidosis has been especially neglected. The recent appearance, from one of the leading diabetic clinics, of a series of papers objecting to the use of glucose in the treatment of diabetic acidoisiS42, 81, 82 has tempted the author to review the subject.t Because Barrenscheen4 and Nagasuye72 found that a single feeding of glucose after a 3-day fast promoted no deposition of glycogen in the livers of dogs, starvation diabetes was first attributed to impairment of hepatic glycogenesis. Subsequent investigations have proved that this deduction was erroneous; the defect lies not in glycogenesis, but in the oxidation of glycogen by the tissues. Although this defect appears to be related to depletion of liver glycogen, this correlation is probably more or less fortuitous. Starvation diabetes seems to come on.when an animal is subsisting upon a diet of fat and protein and is dependent upon the latter for the provision of carbohydrate. By such devious paths and profuse experimental data have these conclusions been reached, that compre-
Source: Europe PMC (PubMed Central)
Author: J P Peters
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W275956612