Get started
Work

Recordings of Caenorhabditis elegans locomotor behaviour following targeted ablation of single motorneurons

Year: 2017
Type: data-paper
Abstract: Lesioning studies have provided important insight into the functions of brain regions in humans and other animals. In the nematode Caenorhabditis elegans, with a small nervous system of 302 identified neurons, it is possible to generate lesions with single cell resolution and infer the roles of individual neurons in behaviour. Here we present a dataset of ~300 video recordings representing the locomotor behaviour of animals carrying single-cell ablations of 5 different motorneurons. Each file includes a raw video of approximately 27,000 frames; each frame has also been segmented to yield the position, contour, and body curvature of the tracked animal. These recordings can be further analysed using publicly-available software to extract features relevant to behavioural phenotypes. This dataset therefore represents a useful resource for probing the neural basis of behaviour in C. elegans, a resource we hope to augment in the future with ablation recordings for additional neurons.
DOI: 10.1038/sdata.2017.156
Authors: Yee Lian Chew, Denise S. Walker, Emma K. Towlson, Petra E. Vértes, Gang Yan, Albert-László Barabási, William R. Schafer
Institutions: MRC Laboratory of Molecular Biology, Northeastern University, University of Cambridge, Tongji University, Brigham and Women's Hospital, Harvard University, Central European University, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center
Language: English
Open Access status: gold
Estimated APC paid: $2,490
Awards: G1940826620, G3108568989, Identifying novel sensory molecules and mechanisms in nematodes and mammals., G3754526185, G9000028377, Caenorhabditis Genetics Center
OpenAlex ID: W2760041144
Cites: 17
Cited by: 21
Related to: 10