Year: 2017
Type: article
Study design: Observational Study
Abstract: // Celina Ang 1 , Anthony Shields 2 , Joanne Xiu 3 , Zoran Gatalica 4 , Sandeep Reddy 3 , Mohamed E. Salem 5 , Carol Farhangfar 6 , Jimmy Hwang 7 , Igor Astsaturov 3, 7 and John L. Marshall 5 1 Department of Medicine, Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA 2 Department of Oncology, Molecular Imaging & Diagnostics Program, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA 3 Department of Medical Affairs, Caris Life Sciences, Phoenix, AZ, USA 4 Department of Pathology, Caris Life Sciences, Phoenix, AZ, USA 5 Hematology/Oncology, Lombardi Comprehensive Cancer Center, Georgetown, University, Washington, DC, USA 6 Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC, USA 7 Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA Correspondence to: Celina Ang, email: [email protected] Keywords: hepatocellular carcinoma; age differences; multiplatform profiling; pathogenic mutations Received: July 03, 2017 Accepted: August 31, 2017 Published: September 27, 2017 ABSTRACT While most patients in Western countries who are diagnosed with HCC are in their 50s and 60s, HCCs diagnosed at extremes of the age spectrum (i.e., < 40 years and ≥ 75 years) are less common and have been linked with distinct geographic locations and etiologies. Using multiplatform profiling, we identified differences in genetic alterations and protein expression in different age groups within a large cohort of HCC patients (N = 421). Young adult HCC patients (18-39 years’ old) were more likely to be female, living in the West and Midwestern United States, and showed decreased androgen receptor, drug resistance and pro-angiogenic protein expression compared to older patients. TP53 mutations were the most frequent alteration in young adults (19%), whereas CTNNB1 mutations occurred in 30-33% of patients ≥ 40 years’ old. The overall frequency of pathogenic and presumed pathogenic mutations was observed to increase significantly with advancing age. To our knowledge, these data represent one of the only studies to analyze age-specific molecular profiles in HCC, and provide a basis for further exploration and validation of these findings with respect to their clinical and therapeutic implications.
Source: Oncotarget
Institutions: Icahn School of Medicine at Mount Sinai, Wayne State University, The Barbara Ann Karmanos Cancer Institute, Caris Life Sciences (United States), Georgetown University, Georgetown Lombardi Comprehensive Cancer Center, Carolinas Healthcare System, Levine Cancer Institute, Fox Chase Cancer Center
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2760192133