Work

Gold‐catalyzed Fluorination of Alkynyl Esters and Ketones: Efficient Access to Fluorinated 1,3‐Dicarbonyl Compounds

Year: 2017

Type: article

Abstract: We developed an efficient synthesis of 2‐fluoro‐1,3‐dicarbonyl compounds using readily available alkynyl ketones or esters as starting material. The key step is the insertion of hydrogen fluoride (HF) to the gold carbene intermediate generated from cationic gold catalyzed addition of N‐oxides to alkynyl ketones or esters. This method gives excellent chemical yields and regioselectivity with good functional group tolerance. magnified image

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.201701179

Authors: Xiaojun Zeng, Zhichao Lu, Shiwen Liu, Gerald B. Hammond, Bo Xu

Institutions: Donghua University, University of Louisville

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green