Objectively Measured Physical Activity, Sedentary Behavior, and Genetic Predisposition to Obesity in U.S. Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Year: 2017
Type: article
Abstract: Studies using self-reported data suggest a gene–physical activity interaction on obesity, yet the influence of sedentary behavior, distinct from a lack of physical activity, on genetic associations with obesity remains unclear. We analyzed interactions of accelerometer-measured moderate to vigorous physical activity (MVPA) and time spent sedentary with genetic variants on obesity among 9,645 U.S. Hispanics/Latinos. An overall genetic risk score (GRS), a central nervous system (CNS)–related GRS, and a non-CNS-related GRS were calculated based on 97 BMI-associated single nucleotide polymorphisms (SNPs). Genetic association with BMI was stronger in individuals with lower MVPA (first tertile) versus higher MVPA (third tertile) (β = 0.78 kg/m2 [SE, 0.10 kg/m2] vs. 0.39 kg/m2 [0.09 kg/m2] per SD increment of GRS; Pinteraction = 0.005), and in those with more time spent sedentary (third tertile) versus less time spent sedentary (first tertile) (β = 0.73 kg/m2 [SE, 0.10 kg/m2] vs. 0.44 kg/m2 [0.09 kg/m2]; Pinteraction = 0.006). Similar significant interaction patterns were observed for obesity risk, body fat mass, fat percentage, fat mass index, and waist circumference, but not for fat-free mass. The CNS-related GRS, but not the non-CNS-related GRS, showed significant interactions with MVPA and sedentary behavior, with effects on BMI and other adiposity traits. Our data suggest that both increasing physical activity and reducing sedentary behavior may attenuate genetic associations with obesity, although the independence of these interaction effects needs to be investigated further.
Source: Diabetes
DOI: 10.2337/db17-0573
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, University of Washington, National Institutes of Health, Gillings School of Public Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Dental and Craniofacial Research, National Institute for Occupational Safety and Health, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G1028935811, G1042216835, G1081972346, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, G1462415530, G1514676350, G1587824183, G1666450717, G1888983140, G1917633662, G2031372691, G2128161193, G2135211244, G2135293100, G2161231279, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2528054427, G2575730562, G2644289446, G2970637568, G3062787641, G307802754, Hispanic Community Health Study, G3677686024, G3692229207, G3838006641, G3952816605, G4121762840, G4165985951, Hispanic Community Health Study, Clinical and Translational Science Coordinating Center, G4438318499, G4552920371, G4860668542, G4989378220, G528357465, G5365244667, G5397198720, G543802643, G555858244, G569253488, G5705373727, G5739677117, G5878028785, HIV Infection, Metabolites and Subclinical Atherosclerosis, G5906656038, G5993399974, G6075306088, G6156511736, G6585687856, G6744188800, G6868531854, G7057037114, G7203655167, G7239480477, G7278742613, G7408420985, G7513901258, G8102260223, G820454163, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, G9000140433, Diabetes Research Center (DRC), NYR-Diabetes Research Center (NYR-DRC), New York Regional Center for Diabetes Translation Research
OpenAlex ID: W2761072647