Year: 2017
Type: article
Abstract: We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation. We harness the strong vertical component of the refracted acoustic wave to enhance cell actuation by using an asymmetric flow field to increase cell deflection. Precise control of the 3-dimensional flow is realized by topographical structures implemented on the top of the microchannel. We experimentally quantify the effect of the structure dimensions and acoustic parameter. The design attains cell sorting rates and purities approaching those of state of the art fluorescence-activated cell sorters with all the advantages of microfluidic cell sorting.
Source: Lab on a Chip
DOI: 10.1039/c7lc00715a
Institutions: Harvard University, University of Glasgow
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Funders: National Science Foundation, Harvard University, Deutsche Forschungsgemeinschaft, Bayerisches Staatsministerium für Umwelt und Verbraucherschutz, Defense Advanced Research Projects Agency, Advanced Research Projects Agency, Materials Research Science and Engineering Center, Harvard University, National Science Foundation of Sri Lanka, Division of Materials Research
OpenAlex ID: W2761093667