Transcription factor ISX mediates the cross talk between diet and immunity
Year: 2017
Type: article
Abstract: Significance The intestine is the major entrance site for nutrients, electrolytes, and water while constituting an effective barrier against toxins, antigens, and enteric flora. Hence, the intestinal mucosa harbors one of the largest populations of lymphocytes in the body. Nutrients such as vitamin A have been recognized to influence gut homing and differentiation of these cells. We identified the ISX protein as a critical molecular mediator of this cross talk between diet and immunity. This transcription factor regulates vitamin A production from dietary precursor molecules. Loss of this control in mice disrupts vitamin A homeostasis and impairs immunity. Reported genetic polymorphisms in the Isx gene have been associated with inflammatory disorders in humans, indicating that our findings in mice have clinical implications.
Institution: Case Western Reserve University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1620361201, G2400197275, G2632193975, G3415023121, G4132518751, G4838978803, Intermediate-Featured Flow Cytometer, G5964505754, G7134157114, Regulation of vitamin A metabolism in the eye, G8732319009, Case Comprehensive Cancer Center Support Grant, CWRU-Visual Sciences Training Program, G907655684
OpenAlex ID: W2761221960