Year: 2015
Type: dissertation
Abstract: DNA methylation is a crucial epigenetic modification involved in numerous biological processes. However, despite its functional importance, the evolutionary history of this modification and the mechanisms diving such changes are poorly understood. The aim of this thesis is to provide a better understanding of DNA methylation in the context of human recent evolution. We identified and described hundreds of regions presenting a human-specific DNA methylation pattern compared to great apes. We also analyzed for the first time the relationship between DNA methylation changes and sequence evolution at both nucleotide and protein level. In summary, this research reveals new insights into the evolutionary properties of DNA methylation and the interpretation of inter-species non-coding variation
Authors: Hernando Herráez, Irene Irene
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G2507953404, G4734419841, G8749328333
OpenAlex ID: W2761289572