Work

Pak2 regulates myeloid-derived suppressor cell development in mice

Year: 2017

Type: article

Abstract: , a well-described myeloid transcription factor. Together, our data reveal a previously unrecognized role of Pak2 in regulating MDSC development via both cell-intrinsic and extrinsic mechanisms. Our findings have potential translational implications, as the efficacy of targeting Paks in cancer therapeutics may be undermined by tumor escape from immune control and/or acceleration of tumorigenesis through MDSC expansion.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2017007435