Year: 2017
Type: editorial
Abstract: Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.
Source: Cell Cycle
Authors: Weiguo Zhang, Gary H. Karpen, Qing Zhang
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Role of the EglN2 Target FOXO3a in Breast Cancer, Role of the EglN2 Target FOXO3a in Breast Cancer, G2800195642, G4119534169, Regulation of Centromere Protein Stability and Impact on Cancer Progression, G5850682332, Exploration of ZHX2 as a novel substrate of pVHL and an oncogenic driver of renal cancer, OTUB1 as a Novel Therapeutic Target in Kidney Cancer by Deubiquitinating HIF2alpha, G9000197499, G9000271451
OpenAlex ID: W2761890327