Year: 2014
Type: dissertation
Abstract: There are a number of interesting sexual dimorphisms studied in the brain, each of which is affected by hormones in different ways. The purpose of this experiment was to investigate the role of overexpressed androgen receptors on the expression of three sexual dimorphisms. The first, tyrosine hydroxylase immunoreactivity in the anteroventral periventricular nucleus and the second, vasopressin immunoreactivity in the lateral septum maintained their respective sex differences; however, they were unaffected by androgen receptor (AR) overexpression. The third, the sexually dimorphic nucleus of the preoptic area, showed an effect on cell size, with an increase in females overexpressing AR. Thus, this study provides evidence that AR affects cell size, often a marker for activational effects, more than it does markers of organizational effects.
Source: TSpace (University of Toronto)
Author: Firyal Ramzan
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2762059123