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Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

Year: 2017
Type: editorial
Abstract: With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions.
DOI: 10.1002/psp4.12206
Authors: B Ribba, HP Grimm, B Agoram, MR Davies, K Gadkar, S Niederer, N van Riel, J Timmis, PH van der Graaf
Institutions: F. Hoffmann-La Roche AG, Genentech, King's College London, Amsterdam UMC Location University of Amsterdam, Eindhoven University of Technology, University of Amsterdam, University of York, Leiden University
Language: English
Open Access status: gold
Estimated APC paid: $4,140
OpenAlex ID: W2762759784
Cites: 10
Cited by: 43
Related to: 10