Work

Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease

Year: 2017

Type: article

Abstract: Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Intriguingly, a very low percentage of drinkers develop clinical pancreatitis. Experimental models demonstrate that alcohol administration alone does not initiate pancreatitis but does sensitize the pancreas to disease. Understanding the effects of alcohol use on the pancreas may prove beneficial in the prevention of both pancreatitis and pancreatic cancer.

Source: Alcohol research

DOI: 10.35946/arcr.v38.2.03

Author: VW Setiawan

Institutions: University of Southern California, Cedars-Sinai Medical Center, University of Pittsburgh, University of Pittsburgh Medical Center

Language: English

Topic: Pancreatitis Pathology and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: U.S. Department of Veterans Affairs, National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases