Work

Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation

Year: 2017

Type: review

Abstract: Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201700733

Authors: Michelle L. Ratay, Elena Bellotti, Riccardo Gottardi, Steven R. Little

Institutions: University of Pittsburgh, Claude Worthington Benedum Foundation, McGowan Institute for Regenerative Medicine

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green