The Suitability of Pyrogen Test in vitro with Human Peripheral Blood Mononuclear Cell for Haemorrhagic Fever with Renal Syndrome Bivalent Vaccine
Year: 2017
Type: article
Abstract: To investigate the suitability of Pyrogen Test in vitro with Human Peripheral Blood Mononuclear Cell (PBMC) for Haemorrhagic Fever with Renal Syndrome Bivalent Vaccine, We collected 9 batches vaccines from different manufacturers. The recovery was determinated by human PBMC- IL-6 in vitro pyrogen test with spiking bacterial endotoxin. The recoveries of batches were between 50%-200%, as the test solutions at a dilution less than the maximum valid dilution (MVD). The results showed all of the 9 batches vaccines were qualified products in pyrogen test. the human PBMC-IL-6 in vitro pyrogen test is suitable for Haemorrhagic Fever with Renal Syndrome Bivalent Vaccine to control the pyrogen.
Source: Journal of Applied Virology
DOI: 10.21092/jav.v6i3.92
Authors: Tong Cai, Yuan Zhang, Qing He, Qian Liu, Yusheng Pei, Chen Chen, Hua Gao
Language: English
Topic: Viral Infections and Vectors
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2763562888