Maternal Tenofovir Disoproxil Fumarate Use During Pregnancy Is Not Associated With Adverse Perinatal Outcomes Among HIV-infected East African Women: A Prospective Study
Year: 2017
Type: article
Abstract: Background: Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and pre-exposure prophylaxis regimens. We evaluated the relationship between adverse perinatal outcomes and prenatal TDF use. Methods: Longitudinal data were analyzed from human immunodeficiency virus (HIV)-infected women who became pregnant during 2 HIV prevention studies conducted among HIV-serodiscordant couples in Kenya and Uganda. Pregnancies included were singleton, not terminated by an induced abortion, and had documented 3-drug ART use. Multivariate generalized estimating equation models were used to determine the association of prenatal TDF and perinatal outcomes. Results: The most frequent ART regimens were TDF/3TC/EFV (39%) and AZT/3TC/NVP (34%); 49% of pregnancies had prenatal TDF exposure and 6% used a protease inhibitor. Neonatal death, preterm birth, and pregnancy loss occurred in 2%, 8%, and 12% of pregnancies, respectively. No differences were observed between pregnancies with and without exposure to TDF in the frequency of pregnancy loss (adjusted prevalence rate ratio [aPRR] 1.19, P = .8) or neonatal death (aPRR 0.68, P = .6). Preterm birth occurred less frequently among pregnancies exposed to TDF (aPRR, 0.34, P = .02). Conclusion: Maternal TDF use did not adversely affect perinatal outcomes.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: United States Agency for International Development, Bill and Melinda Gates Foundation, National Institutes of Health, National Institute of Mental Health, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Delivery of integrated PrEP and ART for HIV prevention for couples in Kenya, Pediatric HIV-1 in Africa: Pathogenesis and Management, Adherence to Pre-Exposure Prophylaxis for HIV Prevention in Pregnancy, Antiretroviral periconception HIV prevention for HIV discordant couples, Delivering PrEP in Pregnancy, University of Washington Foundation - to conduct a placebo-controlled proof-of-concept phase III trial of the safety and efficacy of TDF and FTC/TDF in reducing HIV acquisition among HI..., G7965387109, STD and AIDS Research Training Grant
OpenAlex ID: W2763610440