Work

Postaxial limb hypoplasia (PALH): the classification, clinical features, and related developmental biology

Year: 2017

Type: review

Abstract: Postaxial limb hypoplasia (PALH) is a group of nonhereditary diseases with congenital lower limb deficiency affecting the fibular ray, including fibular hemimelia, proximal femoral focal deficiency, and tarsal coalition. The etiology and the developmental biology of the anomaly are still not fully understood. Here, we review the previous classification systems, present the clinical features, and discuss the developmental biology of PALH.

Source: Annals of the New York Academy of Sciences

DOI: 10.1111/nyas.13440

Authors: Zeng Zhang, Dan Yi, Rong Xie, John L. Hamilton, Qing‐Lin Kang, Di Chen

Institutions: Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, Rush University Medical Center

Language: English

Topic: Congenital limb and hand anomalies

Subfield: Developmental Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Shenzhen Municipal Science and Technology Innovation Council, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases