Year: 2017
Type: article
Abstract: regiospecific activation of halogenated pyridines (or other heterocycles) and conjugate addition to dehydroalanine derivatives to deliver a wide range of unnatural amino acids. This process was conducted with good efficiency on large scale, the application of these conditions to amino ketone synthesis is shown, and a simple protocol is given for the preparation of enantioenriched amino acid synthesis, from a number of radical precursors.
Source: Chemical Science
DOI: 10.1039/c7sc03612d
Authors: R. A. Aycock, D. B. Vogt, N. T. Jui
Institutions: Emory University, Winship Cancer Institute
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W2763994394